A recent study investigates the role of the deubiquitinase OTUB1 in vascular smooth muscle cells (VSMCs) within the context of atherosclerosis, a disease characterized by lipid accumulation and plaque formation in arteries. Atherosclerosis is a major cause of cardiovascular and cerebrovascular diseases, with VSMCs playing a significant role in its development. The research explores the potential of targeting OTUB1 to modulate the phenotype switch of VSMCs, which is considered a critical pathological process in atherosclerosis.
Study: Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ
