When a neuron ages, it loses synaptic connections with other neurons, it is less able to transmit nerve impulses, and its metabolism is also altered. This process of neuronal aging—inevitable with the passing of time—is particularly accelerated and becomes a risk factor in neurodegenerative pathologies such as Alzheimer’s disease. But can the effects of aging be reversed in cells as specialized as neurons?
Cellular reprogramming rejuvenates neurons and enhances synaptic plasticity in mouse study
