A newly developed mouse model enables real-time visualization of RNA Polymerase II (RNAP2) during DNA transcription, as reported by researchers from Science Tokyo. The team engineered mice to produce a fluorescent antibody that binds specifically to RNAP2 during active transcription. Their approach enabled super-resolution imaging of transcription sites in living cells, revealing differences in gene expression dynamics across cell types and developmental states.
Unlocking key insights into gene expression using a novel mouse model
