Cyanide is a highly lethal chemical that has been used in warfare and poisonings for centuries—that was the general consensus on the naturally occurring chemical up until spring 2025. But in a global study published in Nature Metabolism, a research team from seven countries and 12 universities, including South Dakota State University, has upended the world’s consensus on cyanide. The researchers have found that while cyanide remains highly poisonous, it also plays a fundamental role in normal cell function.