A research team has identified STAT1 as a key transcriptional regulator that enhances platelet production from induced pluripotent stem (iPS) cells by epigenetically controlling LIN28A and its downstream let-7-RALB axis. The study, published in Blood Advances, was led by Dr. Si Jing Chen (Chiba University) and Professor Koji Eto (Department of Clinical Application)
Inhibiting STAT1 boosts platelet production via LIN28A-let-7 control
