A research team led by Prof. Xu Pingyong from the Institute of Biophysics of the Chinese Academy of Sciences has developed an innovative approach to visualize and rapidly screen small peptide knockins. The new approach, termed ALFA Nanobody-guided Endogenous Labeling (ANGEL), solves a long-standing problem of high-throughput screening for nonfluorescent small peptide knockins. Results were published in Nature Chemical Biology on August 29.
Nanobody-guided approach enables efficient fluorescent labeling of endogenous proteins
