Antibiotics instead of images: Generative AI designs molecules that kill drug-resistant bacteria

What if generative AI could design life-saving antibiotics, not just art and text? In a new Cell Biomaterials paper, Penn researchers introduce AMP-Diffusion, a generative AI tool used to create tens of thousands of new antimicrobial peptides (AMPs)—short strings of amino acids, the building blocks of proteins—with bacteria-killing potential. In animal models, the most potent AMPs performed as well as FDA-approved drugs, without detectable adverse effects.

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