A research team at Kyoto University has discovered STAG3-cohesin, a new mitotic cohesin complex that helps establish the unique DNA architecture of spermatogonial stem cells (SSCs), the stem cells that give rise to sperm. This “DNA organizer” is crucial for sperm production in mice: without STAG3, SSCs cannot differentiate properly, leading to a fertility problem.
Scientists discover new ‘3D genome organizer’ linked to fertility and cancer
