Scientists at the Department of Energy’s Oak Ridge National Laboratory have reimagined the capabilities of atomic force microscopy, or AFM, transforming it from a tool for imaging nanoscale features into one that also captures large-scale biological architecture. Often called a “touching microscope,” AFM uses a fine probe to feel surfaces at resolutions down to a billionth of a meter. Although powerful, traditional AFM has been limited by its narrow field of view, making it difficult to understand how individual features fit into larger organizational structures.