Deciphering disease progression and cell processes with TIGER, in vivo and non-invasively

Could patients in the future simply ingest a diagnostic probiotic based on programmed ribonucleic acids to analyze their intestinal health from individual cells? Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) and the Julius-Maximilians-Universität (JMU) in Würzburg have developed a new technology they call TIGER. It allows complex processes in individual cells to be deciphered in vivo by recording past RNA transcripts. The findings were published in the journal Nature Biotechnology on January 5, 2023.

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