How the circadian rhythm of the liver is regulated by muscle activity

The biological clock/circadian rhythm is the mechanism that ensures that a certain physiological process takes place at a specific time of the day or night. It is coordinated by the brain at a general level, but each organ or tissue is also subjected to specific regulation. Adjusting to geophysical time is a way to optimize processes, but how does the liver “know” when it is day or night?

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